Composition: 1 ml solution for injection contains:
Dexamethasone-sodium-phosphate 2.64 mg
Indications: Treatment of diseases of the locomotor system of animals, as well as a
variety of inflammation of joints (arthritis, periarthritis, poliarthritis), inflammation of the
tendon sheath and tendon (tendinitis and tendovaginitis), inflammation (bursitis),
inflammation of muscles (myositis), nerves (neuritis), painful injuries: sprains
(dislocations), bruises (contusions), sprains (distortions), broken bones (fractures),
allergic reaction, and ketosis, puerperal paresis, skin diseases and trauma during
delivery. Dexamethasone is used as symptomatic therapy with antibiotics in the
treatment of inflammation of the udder (mastitis) and MMA syndrome of sows, as well as
in the treatment of inflammatory conditions of the respiratory system of horses, cattle,
pigs, dogs and cats.
Contraindications: application of the drug is contraindicated for animals hypersensitive
to glucocorticoids or any component of the drug, in pregnancy (except in gravidity
toxemia), recent surgical procedure (because it prevents the healing of wounds), with
wounds that do not heal, glaucoma, edema, renal and heart failure, diabetes, steroid
diabetes mellitus, hyperadenokorticism, blood dyscrasias, and ulceration of the gastric
mucosa, acute tuberculosis, deep corneal ulcers, osteoporosis and demodicosis. The
drug is not indicated for viral infections (during viremia), as well as laminitis in horses. It
is not given for bacterial infections that were not treated with bactericidal antibiotics.
Side effects: While a single dose of medication is generally well tolerated, its long-term
use can cause serious side effects. Application of high doses of glucocorticoids in the
period of a few weeks may cause suppression of the hypothalamic-pituitary-
adrenocortical shaft. System use of corticosteroid, particularly at the beginning of
therapy with this drug can cause polyuria, polidipsya and polifagya. Later there may
appear a weakness of the muscles, osteoporosis and lethargy, as well as the
appearance of hemorrhagic gastroenteritis, pancreatitis, dysfunction of liver and kidneys.
There may occur glycosuria, leukopenia, trombocitopeny.Because of
immunosuppressive effects of corticosteroids susceptibility of animals to bacterial and
viral infections is increased. At long term usage its possible retention of sodium and
water, with consequent edema. May cause anaphylactic reactions, in which case you
should immediately apply adrenalin.
Target species: horses, cattle, pigs, dogs and cats,
Dosage and method of administration:
The drug is given intramuscularly or locally in the burned tissue (intraarticular,
perarticular, intrabursal) in a daily dose of:
Horses, cattle: 2.5 mL/100kg body weight local 2-4ml
Foals, calves: 0.5 mL/10kg body weight local 1-2ml
Pigs: 0.5 mL/10kg body weight local 1-2ml
Cats & Dogs: 0.25 mL/5kg body weight local 0.25-1ml
The drug is administered once, but depending on the severity of the inflammatory
process, in large animals dose can be repeated after 1 – 2 days, pigs and dogs after 1-2
days, and in cats after 2-3 days.
Instructions for proper use of drugs: Therapy implement with the recommended
therapeutic doses, because any increase in dose causes unwanted harder effects.
Intraarticular use of this drug performed under strict aseptic conditions, and since
exclude bacterial infection, fracture or aseptic necrosis of the bone. Be careful in the
treatment of various inflammatory conditions because dexamethasone, as well as other
glucocorticosteroids, may mask the clinical picture and thus facilitate the spread of
The application of high doses of glucocorticoids in the period of a few weeks may cause
suppression of the hypothalamic-pituitary-adrenocortical axis. Because of that it is
recommended to gradually reduce the dose of glucocorticoids until the therapy ends.
Withdrawal period: Meat of treated cattle and pigs is not for human consumption during
treatment or for 21 days after the last application of medicine. Milk of cows is not for
human consumption during treatment or 84 hours after the last application of medicine.
Medicine is not given to horses whose meat is intended for human consumption.
For use on animals: When given to cows in lactation it reduces milk production during
3-5 days, with what animal owners must be familiar. All glucocorticoids, including
dexamethasone can cause laminitis at susceptible horses.
It is not given 24 hours before the race.
Estrogens potentiate the effect of glicocortikoids when used simultaneously. NSAIL
potentiate the side effects of glicocortikoids on digestive system. Glicocortikoids reduce
the efficiency of bacteriostatic antibiotics. Corticosteroids are not applied at the time of
vaccination and 3-4 weeks before and after vekcination, due to its immunosupressive
effects.Antihistamines and barbiturates stimulate metabolism corticosteroids by induction
of liver enzymes, and thus reduce the activity dexamethasone. On the other hand, the
use of dexamethasone reduces the time of barbiturates.
Use during pregnancy and lactation
Do not recommend the use of corticosteroids during gravidity.The drug applied in early
pregnancy can cause fetal malformations.In the last third of pregnancy can cause
premature birth, fetal death, placental retention and metritis.At lactating cows can lead to
a reduction in milk production.
Special considerations for people who give animals medicine
Avoid direct contact with the product.Wash hands after application.Do not eat or drink
while handling with product.In case of contact with eyes, they should be immediately
flushed with water.
Special precautions for disposal and destruction of drug
Unused drug or drug residues shall be destroyed in accordance with applicable
Storage: Store in original container at temperatures up to 25 °C, out of reach of children.
Shelf life: 2 years.
Shelf life after first opening: 28 days at temperatures up to 25 ˚C
Method of issuance: On prescription of veterinarian
Packaging: Glass bottle of 20 mL and 50 mL.
ATCvet code: QH02AB02
Number and date:
1x 20ml 323-01-0591-11-002 date 25.07.2012.
1x 50 mL 232-01-0592-11-002 date 25.07.2012.
Producer: “FM Pharm”, Subotica, 024/548-130
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