Composition: 1 ml injection solution contains:
Metamizol sodium 500 mg
Indications: The drug is indicated for the treatment of painful conditions of the
locomotor apparatus: myalgia, arthralgia, acute inflammation of the tendons and tendon
sheaths, lumbago of the horse; spasm of the gastrointestinal tract (due catarrhal
enteralgy, tonic spasms of the intestines, constipation, dilatation of the stomach of
horses, cattle and pigs, intestinal meteorism of ruminants, pharyngeal and
ezopharyngeal spasm (obstruction) in cattle, horses and pigs; spastic condition of the
uterus (distoction at sows and sheep) and spastic condition of urinary tract. It’s also used
at fevers of different etiology (mastitis, MMA sows), for reduction of pain during the
examination or treatment of animals as well as symptomatic therapy for bacterial
Contraindications: The use of this drug is contraindicated at animals with impaired
renal function, heart and liver, the changes in blood chemistry (blood dyscrasias),
gastroenteritis and existing hemorrhage regardless of origin, as well at dehydrated and
exhausted animals. The use of this drug for cats is contraindicated.
The drug is not given to sport horses for at least 5 days before the race.
The drug is not administered to puppies younger than 6 weeks by horses whose meat is
intended for human consumption.
Side effects: Prolonged use of metamisole may cause agranulocytosis, ulcerative
gastroenteritis, vomiting, bleeding, impaired kidney and liver functions. High doses of
this drug, because of hyper-arousal of the central nervous system, can cause tremors,
and rarely, it can cause paresis. In place of i.m. application metamizol is leading to
irritation and tissue edema, which spontaneously passes within a few days.
Target species: horses, cattle, sheep, goats, pigs and dogs.
Dosage and method of administration: The drug is administered intravenously and
intramuscularly. At severe pain and spasm of smooth muscles, the drug should be
applied slowly intravenously. In other cases, we recommend a combination of both types
The drug is administered in a dosage that is for:
Horses: 4-10 ml per 100 kg of body weight; i.v.
Cattle: 4-8 ml per 100 kg of body weight; i.v.; i.m.
Foals, calves: 1.5 – 5 ml per 50 kg of body weight i.v.; i.m.
Sheep and goats: 1-2 ml per 25 kg of body weight i.v.; i.m.
Pigs: 1.5 – 5 ml per 50 kg of body weight, i.m.
Dogs: 0.5-1 ml per 10 kg of body weight; i.v.; i.m.
The drug is applied once a day. If necessary, the dose may be given three times a day,
at intervals of 8 hours. Therapy usually takes 3 to 5 days.
Instructions for proper use of drugs: If the medicine is applied intramuscularly, at one
injection site do not give more than: 20 mL for horses and cattle, 10 ml for pigs, sheep
and goats and 5 ml for dogs. Subcutaneous administration of preparation is not
recommended because of the strong local irritation of tissue. It is applied slowly
Meat of bovine animals: 18 days after the last application of the medicine.
Meat of horses and pigs: 15 days after the last application of the drug
The drug is not indicated for animals whose milk is used for human consumption.
For use on animals
The drug should not be used concurrently with barbiturates and phenothiazines,
because these drugs reduce the activity time of metamisol. It is not applied with other
nestereoid anti-inflammatory drugs, because they antagonize its therapeutic effects and
summarize or emphasize the toxic side effects. Do not apply simultaneously with
glucocorticoids, aminoglycosides and any other nephrotoxic drug.
Use during pregnancy and lactation
The drug is not given to dairy animals while in lactation whose milk is used in the human
diet, in the dry period and to pregnant cows 2 months before parturition.
Special considerations for persons administering the veterinary medicinal product
When applying the drug you should avoid direct contact with skin and mucous
membranes, or eyes. After each application hands should be washed. Avoid contact with
the drug if there is a hypersensitivity to pyrazolone derivatives and aspirin. In case of the
signs of hypersensitivity consult a specialist.
Special precautions for disposal and destruction of drug
Unused drug or drug residues shall be destroyed in accordance with applicable
Storage: Keep in original packaging, at temperatures up to 25 ° C, out of reach of
Shelf life in original packaging: 2 years.
Shelf life after opening: 28 days.
Method of issuance: On prescription of veterinarian.
Packaging: Bottle of 50 mL and 100 mL, bottle of 250 mL.
ATCvet code: QN02BB02
Number and date of registration:
1×50 mL 323-01-00223-15-001 date 04.11.2015
1×100 mL 323-01-00224-15-001 date 04.11.2015
1×250 mL 323-01-00225-15-001 date 04.11.2015
Producer: “FM Pharm”, Subotica, 024/548-130
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