Neostrep L.A.


Neostrep L.A.

Composition: 1 ml suspension for injection contains:

Procaine – benzylpenicillin 120.000 i u

Benzathine – benzylpenicillin 80000 i.u

Dihydrostreptomycin sulfate 200 mg

Indications: Treatment of primary and secondary bacterial infections of the respiratory,

urinary and digestive tract caused by microorganisms sensitive to the active ingredients

of the drug at horses, cattle, sheep and pigs.

Contraindications: The drug is not administered to animals hypersensitive to penicillins,

cephalosporins, and dihydrostreptomycin. The drug is not given to pregnant sows and

gilts, sport horses 2 weeks before the race, small herbivores (rabbits, guinea pigs,

gerbils and hamsters), and animals with well advanced gravidity to avoid hearing loss in

newborns animals.Not applied to animals with impaired renal, liver, impaired hearing,

impaired balance, as well as high gravidity.Not used for sheep whose milk is used for

human consumption or horses intended for human consumption.

Side effects: At animals, they can cause hypersensitivity reactions (allergy,

anaphylaxis), and nerve disorders (anxiety, uncoordinated movements, vomiting,

cramps, hearing impairment), possible vaginal washing and abortions in sows and gilts.It

is possible diarrhea in all target species. Pigs are especially sensitive to them, and the

drug may cause hyperpyrexia, vomiting, swelling of the vulva, cyanosis of the extremities

and even abortion.

At the injection site it may cause transient irritation of tissues.

Target species: horses, cattle, sheep and pigs.

Dosage and method of administration: Its applied once, in the deep intramuscular

dose of the:

Horses and cattle 5-10 ml/100 kg of body weight

Pigs and sheep 5 mL/50 kg of body weight

If necessary, drug application may be repeated after 3-4 days. For complete therapy are

usually sufficient 2-3 drug applications.

Instructions for proper use of drugs:

Before applying medication mix well.

The drug should be exclusively applied by deep intramuscular. Do not give the drug

itravenous and intratraheals.If the dose for cattle and horses is greater than 20 mL for

pigs of 10 mL and 5 mL for sheep-drug is administered at least at two injection places.If

allergic reaction occurs, immediately apply adrenalin and antihistamines as needed and

glukokortikoids.Animals allergic to this drug should not be treated any other beta-lactam


Withdrawal period: Meat and edible organs of the treated animals are not for human

consumption during treatment applications, as well as 30 days after the last application

of the medicine. Milk of treated cows is not used for human consumption during

treatment or 7 days after the last application of the medicine.Not given to sheep in

lactation if milk is used for human consumption.Drug is not given to horses whose meat

is intended for human consumption

Special considerations:

For use in animals:

Acids, bases and oxidizing agents inactivated preparation.

Tetracyclines, sulfonamides, macrolides and lincosamides exhibit antagonistic effect of

the active components of this drug.Penicilin enhances the effect of anticoagulation

supstances. Nafcilin, methicillin, koksicilin, cephalosporins, aminoglycosides and

polymyxin B enhance antimicrobial activity of penicilin. Dihidrostreptomicin amplifies the

effect of muscle relaxants and ethacrynic acid and furosemide increase the ototoxic

effect this antibiotic.Acids and bases inactivate dihidrostreptomicin.Drug is not given

with general anesthetics, muscle relaxant medicines and preparations of magnesium.

Use of high doses may cause leukopenia and agranulocytosis.Only multiply exceeding

ofthe prescribed dose causes overdose symptoms (difficulty breathing, hypersalivation,

excitation, convulsions and seizures). Therapy should be stopped immediately and

symptomatic treatment should be applied.Overdosage of preparation and application in

the course of time longer than the recommended can cause an imbalance and reversible

deafness in treated animals.

Use in pregnancy and lactation:

The drug can be used in pregnancy and during lactation, but with caution because of

possible hearing damage of fetus.Drug is not applied in advanced pregnancy because it

can cause deafness in newborns.

At this medication are especially susceptible pigs after the application of which can lead

to abortion and therefore its use is contraindicated in pregnant sows and gilts.Not given

to sheep in lactation if milk is used for human consumption.

Special considerations for persons administering the veterinary medicinal product

to animals:

In the event that contamination occurs, immediately wash the area with soap and water.

People with an established allergy to penicillins, aminoglycosides and cephalosporins

should avoid contact with the drug and should not handle this medicine without a

protective gloves.In case of allergy (skin rash, swelling of lips and eyelids) it is necessary

to seek medical advice.

Special precautions for disposal and destruction of drug

Unused drug or drug residues shall be destroyed in accordance with applicable


Special considerations for storing drugs:

Store in original container at temperatures up to 25˚C

Keep out of the reach of children.

Method of issue: on prescription of veterinarian.

Shelf life: 2 years.

Shelf life after opening: 28 days

Packaging: bottle of dark glass type II of 100 mL and 50 mL, closed with bromobutyl

rubber stopper and aluminum cap

ATC vet code: QJ01RA01

Number and date of registration: 1×50 mL 16/2011/1400 date 10.01.2011

1×100 mL 15/2011/1400 date 10.01.2011

Producer: “FM Pharm”, Subotica, 024/548-130



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