Composition: 1 ml suspension for injection contains:
Benzylpenicillin-procaine 200.000 iu
Dihydrostreptomycin 200 mg
Indications: The preparation is intended for the treatment of acute and chronic mixed,
primary and secondary infections of the respiratory, urinary and gastrointestinal tract and
soft tissue skin infections caused by microorganisms sensitive to the active substance in
Contraindications: The drug is not administered to animals hypersensitive to penicillins,
cephalosporins, and aminoglycosides, as well as to animals with impaired kidney, liver
and cohleovestibular apparatus.Not should be used in pregnant sows and gilts because
it can cause vaginal washing and abortus.Not given to small herbivores (guinea pig,
hamster, gerbil). The preparation is not given to quite young animals and racehorses 2
weeks before the race. The drug is not indicated for sheep and goats whose milk is used
for human consumption.Do not give to horses whose meat is used for human
Do not give medication intravenously.
Side effects: At animals that received NEOSTREP they may develop hypersensitivity
reactions (allergy, anaphylaxis), and nerve disorders (anxiety, uncoordinated
movements, vomiting, cramps, hearing loss). At this medication are especially
susceptible pigs where, after the application, can occur hyperpyrexia, vomiting, swelling
of the vulva, cyanosis of the extremities. At pregnant sows and gilts there may occur
vaginal washing and abortion. At the site of drug administration, local reaction is
possible, that spontaneously passes.
Horses,cattle,sheep,goats,pigs and dogs.
Dosage and method of administration: The drug is applied intramuscularly once a day
at the rate of 0.5 to 1 ml / 10 kg body weight for all target species. The application is
repeated daily for 5 days.
Instructions for proper use of drugs:
Shake the bottle before use.
Do not exceed the recommended dose.
If the dose for cattle and horses greater than 10 ml, pigs, sheep, goats and 5 ml, and 2
ml for dogs medicine is applied on more injection sites.
Do not use this medication simultaneously with bacteriostatic drugs (tetracyclines,
sulfonamides, macrolides, lincosamids) due to the antagonistic action.
It may be associated with allergic reactions. In this case apply antihistamines and
Withdrawal period: The meat of treated animals is not for human consumption during
treatment and 30 days after the last administration of the drug. Milk should not be used
for human consumption during treatment and 4 days after the last application of the
medicine.The meat of treated horses is not used for human consumption.
The drug is not used in sheep and goats whose milk is used for human consumption.
For use in animals:
It is possible allergic reaction to drug. In this case antihistamines and glukokortikoides
should be applied. On this medication are especially susceptible pigs at which may occur
after the use of hyperpyrexia, vomiting, swelling of the vulva, cyanosis of the extremities
and even abortus.Should not be used at the same time as bacteriostatic drugs
(tetracyclines, sulfonamides, macrolides, lincosamides) due to the occurrence of
antagonism. Penicillin enhances the effect of anticoagulation substances. Nafcilin,
methicillin, koksicilin, cephalosporins, aminoglycosides and polymyxin B enhance
antimicrobial activity penicilina.Drug does not apply to any myorelaxants, magnesium
salts and general anesthetics because potentiation of neuromuscular paralysis, which
usually causes dihidrostreptomicin.Also, do not apply at the same time or with a diuretic
furosemide and other potentially nephrotoxic and ototoxic drugs.Acides and bases
inactivate dihydrostreptomycin .
In the absence of incompatibility studies, the drug must not be mixed with other
veterinary medicinal products.
Use in pregnancy and lactation:
The drug can be used in pregnancy and during lactation, but with caution because of
possible hearing damage of fetus.At pregnant sows and gilts it can cause vaginal
washing and abortion.
Special considerations for persons administering the veterinary medicinal product
After injection, inhalation, ingestion or topical application at allergic people penicillins
may cause reactions of hypersensitivity.Persons hypersensitive to penicillins may also
be oversensitive on cefalosporine.Alergic reactions to these antibiotics are sometimes
very severe so in such circumstances you should seek medical help.Persons with known
hypersensitivity to penicillins and cephalosporins should not shake hands with them
because caused anaphylactic reactions can be hazardous to life.After application of the
drug hands should be washed with soap and water, and better protection is achieved by
wearing protective gloves.
Special precautions for disposal and destruction of drug
Unused drug or drug residues shall be destroyed in accordance with applicable
Storage: Store in original container at temperatures up to 25 ° C, out of reach of
Shelf life in original packaging: 2 years.
Shelf life after first opening: 28 days at temperatures up to 25 ˚ C
Method of issue: on prescription of veterinarian.
Packaging: bottle of dark glass type II of 100 mL, closed with bromobutyl rubber
stopper and aluminum cap .
ATCvet code: QJ01RA01
Number and date of registration:
NEOSTREP a 100ml 323-01-0635-11-001 date 25.07.2012.
Producer: “FM Pharm”, Subotica, 024/548-130